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Beta-arrestin 1/2 Peptide
產品名稱 : Beta-arrestin 1/2 Peptide
產品類別 : 目錄多肽
品  牌 : ABBIOTEC
貨  號 : 300120
規  格 : 0.1 mg
詳細信息
序  列 The synthetic peptide used to raise the antibody Cat. No. 251344 is selected from a sequence within the center region of human beta-arrestin 1/2. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended.
分  子  式 C70H125N25O19
分  子  量 1620.9 g/mol
純  度 Purity > 80% by HPLC
形  態 Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
溶  解 Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile.
保存條件 Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C.
別  名 beta-arrestin 1; beta-arrestin 2; beta-arrestin 1/2; Beta-arrestin-1/2; Beta-arrestin-1; Arrestin beta-1; ARRB1; Beta-arrestin-2; Arrestin beta-2; ARRB2
產品鏈接 http://www.ABBIOTEC.com/peptides/beta-arrestin-12-peptide
產品說明
產品描述 Beta-arrestins function in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein. Beta-arrestin binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adaptor protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). This antibody recognizes beta-arrestin-1 and beta-arrestin-2. The extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type.
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